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ATTY Rabbit pAb (bs-1907R)  
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產品編號 bs-1907R
英文名稱 ATTY Rabbit pAb
中文名稱 細胞酪氨酸轉氨酶抗體
別    名 TYROSINE AMINOTRANSFERASE; tyrosine aminotransferase; MGC37772; MGC37789; MGC37790; MGC37819; MGC37828; MGC37842; TAT; ATTY_HUMAN; L-tyrosine:2-oxoglutarate aminotransferase; TAT; Tyrosine aminotransferase; Tyrosine aminotransferase, cytosolic.  
研究領域 細胞生物  神經生物學  信號轉導  激酶和磷酸酶  合成與降解  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,Rat (predicted: Human,Cow)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 50 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Tat: 151-250/454 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked.

Function:
Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has no transaminase activity towards phenylalanine.

Subunit:
Homodimer (Probable).

DISEASE:
Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:276600]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.

Similarity:
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

SWISS:
P17735

Gene ID:
6898

Database links:

Entrez Gene: 6898 Human

Entrez Gene: 234724 Mouse

Entrez Gene: 24813 Rat

Omim: 613018 Human

SwissProt: P17735 Human

SwissProt: Q8QZR1 Mouse

SwissProt: P04694 Rat

Unigene: 161640 Human

Unigene: 28110 Mouse

Unigene: 9947 Rat



產品圖片
Sample: Lane 1: Mouse Liver tissue lysates Lane 2: Mouse Heart tissue lysates Lane 3: Rat Spleen tissue lysates Lane 4: Rat Cerebrum tissue lysates Primary: Anti-ATTY (bs-1907R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kDa Observed band size: 52 kDa
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